Research on the antioxidant activity of metabolites from a sponge-derived fungus Alternaria sp. F49 - Details

author：

Chen, Y.-S. (Chen, Y.-S..) ^[1] | Leng, J.-R. (Leng, J.-R..) ^[2] | Lin, S.-T. (Lin, S.-T..) ^[3] | Wang, S.-Y. (Wang, S.-Y..) ^[4] | Tian, Y.-Q. (Tian, Y.-Q..) ^[5] (Scholars：田永奇)

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Abstract：

To　study　the　chemical　constituents　from　the　the　deep-sea　fungus　Alternaria　sp.　F49.　Seven　compounds　were　isolated　from　the　EtOAc　extract　by　using　silica　gel,　Sephadex　LH-20,　ODS　and　HPLC　methods.　Based　on　the　spectroscopic　analysis,　their　structures　were　identified　as　(8R)-5-O-methyl-orcinotriol　(1),　orcinotriol　(2),　α-acety-lorcinol　(3),　3＇-hydroxyalternariol　5-O-methyl　ether　(4),　altenusiol　(5),　altenusin　(6),　and　5＇-methoxy-6-methyl-biphenyl-3,4,3＇-triol　(7).　(8R)-5-O-Methyl-orcinotriol　(1)　is　a　new　phenolic　compound　which　has　never　been　reported　in　the　literature.　Compounds　4-7　showed　strong　DPPH　free　radical　scavenging　activity;　whereas　compounds　1-7　showed　strong　ABTS　free　radical　scavenging　activity.　©　2022,　Chinese　Pharmaceutical　Association.　All　rights　reserved.

Keyword：

ABTS free radical scavenging activity; Alternaria sp F49; DPPH free radical scavenging activity; secondary metabolite; sponge-derived fungus

Community：

[ 1 ] [Chen, Y.-S.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Leng, J.-R.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Lin, S.-T.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 4 ] [Wang, S.-Y.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 5 ] [Tian, Y.-Q.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China

Reprint 's Address：

田永奇
[Tian, Y.-Q.]College of Biological Science and Engineering, China

Email：

tianyongqi@fzu.edu.cn

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Source ：

Yaoxue Xuebao

ISSN： 0513-4870

CN： 11-2163/R

Year： 2022

Issue： 7

Volume： 57

Page： 2120-2125

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 0

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生物科学与工程学院本学院/部未明确归属的数据

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