Dual inhibition of glycolysis and oxidative phosphorylation by aptamer-based artificial enzyme for synergistic cancer therapy - Details

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Abstract：

Dual　inhibition　of　glycolysis　and　oxidative　phosphorylation　(OXPHOS)　can　break　the　metabolic　plasticity　of　cancer　cells　to　inhibit　most　energy　supply　and　lead　to　effective　cancer　therapy.　However,　the　pharmacokinetic　difference　among　drugs　hinders　these　two　inhibitions　to　realize　a　uniform　temporal　and　spatial　distribution.　Herein,　we　report　an　aptamer-based　artificial　enzyme　for　simultaneous　dual　inhibition　of　glycolysis　and　OXPHOS,　which　is　constructed　by　arginine　aptamer　modified　carbon-dots-doped　graphitic　carbon　nitride　(AptCCN).　AptCCN　can　circularly　capture　intracellular　arginine　attribute　to　the　specific　binding　ability　of　arginine　aptamers　to　arginine,　and　further　catalyze　the　oxidation　of　enriched　arginine　to　nitric　oxide　(NO)　under　red　light　irradiation.　In　vitro　and　in　vivo　experiments　showed　that　arginine　depletion　and　NO　stress　could　inhibit　glycolysis　and　OXPHOS,　leading　to　energy　blockage　and　apoptosis　of　cancer　cells.　The　presented　aptamer-based　artificial　enzyme　strategy　provides　a　new　path　for　cell　pathway　regulation　and　synergistic　cancer　therapy.　[Figure　not　available:　see　fulltext.].　©　2022,　Tsinghua　University　Press.

Keyword：

aptamers; artificial enzymes; cancer therapy; energy blockage; photochemistry

Community：

[ 1 ] [Fang, X.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Yuan, M.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Dai, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 4 ] [Lin, Q.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 5 ] [Lin, Y.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 6 ] [Wang, W.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 7 ] [Jiang, Y.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 8 ] [Wang, H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 9 ] [Zhao, F.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 10 ] [Wu, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 11 ] [Bai, S.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 12 ] [Lu, C.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 13 ] [Yang, H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China

Reprint 's Address：

[Lu, C.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, China; ; MOE Key Laboratory for Analytical Science of Food Safety and Biology, China; 电子邮件: hhyang@fzu.edu.cn

Email：

chunhualu@fzu.edu.cn Yang, H.

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Source ：

Nano Research

ISSN： 1998-0124

Year： 2022

Issue： 7

Volume： 15

Page： 6278-6287

9 . 9

JCR@2022

9 . 6 0 0

JCR@2023

ESI HC Threshold：55

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 0

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