Clinically,　systemic　antibiotic　therapy　and　traditional　dressings　care　are　not　satisfactory　in　treating　chronic　diabetic　ulcers　(DU).　Therefore,　we　presented　sprayable　antibacterial　hydrogel　for　effective　treatment　of　DU　by　using　antibacterial　macromolecules　(quaternized　chitosan,　QCS,　Mn　≈　1.5　×　105),　photothermal　antibacterial　nanoparticles　(ε-poly-L-lysine　grafted　graphene　quantum　dots,　GQDs-ε-PL)　and　miocompatible　macromolecules　(benzaldehyde-terminated　four-arm　poly(ethylene　glycol),　4　arm　PEG-BA)　as　materials.　The　results　revealed　that　the　hydrogel　could　be　in　situ　formed　in　70–89　s　through　dynamic　imine　bonds　crosslinking　and　exhibited　a　pH-dependent　swelling　ability　and　degradability.　The　hydrogel　could　respond　to　bacterial　triggered　acidic　environment　to　play　a　synergistic　effect　of　chemotherapy　and　xenon　light　irradiated　PTT,　leading　to　the　rupture　of　the　bacterial　membrane　and　the　inactivation　of　bacteria,　promoting　the　migration　and　proliferation　of　fibroblast　cell,　enhancing　the　adhesion　of　platelet　endothelial　cell,　and　finally　accelerating　the　healing　of　infected　diabetic　wound.　Moreover,　the　hydrogel　displayed　self-healing,　hemostatic,　and　biocompatible　abilities,　which　could　provide　a　better　healing　environment　for　wound　and　further　promote　wound　healing.　Hence,　the　multifunctional　hydrogel　is　expected　to　be　a　potential　dressing　for　the　clinical　treatment　of　DU.　©　2022