In　the　long　process　of　human　evolution,　the　Intestinal　Bacteria　has　become　intimately　related　to　human　health,　producing　many　metabolites　in　the　intestines　that　can　affect　cardiovascular　disease.　Today,　the　incidence　of　cardiovascular　disease　is　rising,　its　treatment　is　becoming　increasingly　important,　and　new　therapeutic　targets　are　needed.　Here　we　describe　the　effects　of　trimethylamine　oxide　(TMAO),　lipid　metabolism,　phenolic　compounds,　indole　sulfate　(IS),　oleuropein　(OL),　and　hydroxytyrosol　(HT)　on　atherosclerosis,　heart　failure,　hypertension,　and　other　cardiovascular　diseases,　as　well　as　their　mechanism　of　action.　This　study　provides　new　ideas,　new　methods,　and　new　directions　for　the　treatment　of　cardiovascular　disease.