Fluoroalkyl-containing　organic　compounds　have　exhibited　wide　applications　in　the　field　of　pharmaceuticals,　agrochemicals　and　materials　science　due　to　their　outstanding　properties　such　as　biological　activity,　metabolic　stability,　lipophilicity,　excellent　chemical　and　thermal　stability.　Therefore,　various　synthetic　strategies　have　been　developed　for　the　construction　of　fluoroalkyl-containing　compounds,　using　highly　active　fluorinating　reagents　and　fluorinated　building　blocks.　Recently,　the　use　of　easily　available　and　inexpensive　trifluoroacetic　anhydride　(TFAA)　and　its　anhydride　analogues　has　attracted　great　attention　to　access　numerous　fluoroalkyl-containing　compounds　through　cyclization　and　coupling　reactions.　In　this　review,　we　summarized　the　recent　advances　in　the　synthesis　of　fluoroalkylated　compounds　using　fluoroalkyl　anhydrides　as　reagents.　This　review　aims　to　provide　a　reference　for　researchers　on　how　to　develop　new　synthetic　straregies　of　fluorine-containing　organic　compounds　and　achieve　kilograms　or　even　tons　preparation　of　fluorine-containing　organic　compounds　using　fluoroalkyl　anhydrides.　(C)　2022　Published　by　Elsevier　B.V.　on　behalf　of　Chinese　Chemical　Society　and　Institute　of　Materia　Medica,　Chinese　Academy　of　Medical　Sciences.