Copper-mediated three-component synthesis of 2-trifluoromethyl benzimidazoles - Details

author：

You, Chenhui (You, Chenhui.) ^[1] | Huang, Yangjie (Huang, Yangjie.) ^[2] | You, Yi (You, Yi.) ^[3] | Weng, Zhiqiang (Weng, Zhiqiang.) ^[4]

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Abstract：

A　copper-mediated　three-component　reaction　of　o-iodoanilines,　anilines,　and　ethyl　trifluoropyruvate　is　reported.　The　transformation　allows　diverse　substrate　scope　on　both　o-iodoanilines　and　anilines,　delivering　various　2-trifluoromethylbenzimidazole　products　in　moderate　to　good　yields.　Mechanistic　studies　suggest　that　this　transformation　proceeds　via　condensation　of　o-iodoaniline　with　ethyl　trifluoropyruvate,　followed　by　an　intermolecular　Ullmann-type　cross-coupling　reaction　with　aniline　and　intramolecular　amination.　©　2022　The　Royal　Society　of　Chemistry

Keyword：

Aniline Chemical reactions Copper

Community：

[ 1 ] [You, Chenhui]Fujian Engineering Research Center of New Chinese Lacquer Material, College of Materials and Chemical Engineering, Minjiang University, Fuzhou; 350108, China
[ 2 ] [You, Chenhui]Key Laboratory of Molecule Synthesis and Function Discovery, and Fujian Provincial Key Laboratory of Electrochemical Energy Storage Materials, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 3 ] [Huang, Yangjie]Fujian Engineering Research Center of New Chinese Lacquer Material, College of Materials and Chemical Engineering, Minjiang University, Fuzhou; 350108, China
[ 4 ] [You, Yi]Key Laboratory of Molecule Synthesis and Function Discovery, and Fujian Provincial Key Laboratory of Electrochemical Energy Storage Materials, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 5 ] [Weng, Zhiqiang]Fujian Engineering Research Center of New Chinese Lacquer Material, College of Materials and Chemical Engineering, Minjiang University, Fuzhou; 350108, China
[ 6 ] [Weng, Zhiqiang]Key Laboratory of Molecule Synthesis and Function Discovery, and Fujian Provincial Key Laboratory of Electrochemical Energy Storage Materials, College of Chemistry, Fuzhou University, Fuzhou; 350108, China

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Source ：

Organic Chemistry Frontiers

ISSN： 2052-4110

Year： 2022

Issue： 12

Volume： 9

Page： 3247-3254

5 . 4

JCR@2022

4 . 6 0 0

JCR@2023

ESI HC Threshold：74

JCR Journal Grade：1

CAS Journal Grade：1

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 1

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