A　large　amount　of　high　saline　solutions　has　been　generated　in　various　industries　and　management　of　hypersaline　solutions　is　a　critical　issue.　Membrane　distillation　(MD)　integrated　with　crystallization　(MDC)　technology　is　a　promising　approach　in　the　treatment　of　hypersaline　solutions,　while　membrane　scaling　is　still　problematic.　Herein,　MDC　assisted　by　ultrasound　(US)　was　proposed　to　deal　with　25.93　wt%　NaCl　solution,　and　the　performance　of　four　processes　including　MD,　US　+　MD,　MDC　and　US　+　MDC　were　systematically　evaluated.　Results　showed　that　ultrasound　and　crystallization　could　effectively　alleviate　membrane　fouling　and　the　operation　time　was　extended　from　80　min　to　over　245　min.　Compared　with　MD　process,　the　weight　of　crystals　on　the　membrane　surface　was　significantly　reduced　in　the　presence　of　US　or　/　and　crystallization　(by　61.24%–98.63%)　while　the　water　recovery　rate　increased　by　122%　with　the　help　of　ultrasound.　Crystal　characteristic　analysis　demonstrated　that　the　average　crystal　size　was　narrow　in　crystallizer　of　US　+　MDC　process,　successfully　verifying　the　stability　and　feasibility　of　the　system.　The　superiority　of　US　+　MDC　process　was　further　confirmed　by　scanning　electron　microscopy　—　energy　dispersive　spectroscopy　observation.　Moreover,　higher　mechanical　strength　and　more　stable　surface　tension　showed　that　US　+　MDC　process　had　a　potential　application　in　treating　hypersaline　solution.　©　2022　Elsevier　B.V.