Membrane　distillation　(MD)　is　emerging　as　a　promising　technology　for　wastewater　reclamation　to　relieve　the　shortage　of　freshwater.　However,　due　to　the　contamination　of　semi-volatile　organic　compounds　(s-VOCs),　part　of　s-VOCs　would　transfer　the　membrane　and　impact　the　permeate　quality　during　the　MD　process.　Herein,　an　innovative　AgCl/MIL-100(Fe)/PTFE　photocatalytic　membrane　(AM/PTFE)　was　rationally　synthesized　in　view　of　the　increasing　s-VOCs　rejection.　The　AM/PTFE　membrane　was　applied　in　the　photocatalytic　direct　contact　membrane　distillation　(DCMD)　system　and　nitrobenzene　(NB)　was　selected　as　the　model　contamination　for　evaluating　removal　performance　of　s-VOCs　under　visible　light.　Compared　with　the　MD　process,　NB　removal　rate　increased　from　63.44%　to　87.84%　in　the　photocatalytic　MD　system.　Moreover,　stable　performance　was　maintained　over　five　NB　removal　cycles　experiment　with　s-VOCs　rejection　higher　than　84.84%　in　the　end.　The　enhanced　rejection　of　s-VOCs　could　be　attributed　to　the　combination　of　adsorption　and　photocatalytic.　The　volatile　NB　molecules　were　adsorbed　on　the　surface　of　photocatalytic　membranes,　and　the　photo-electrons　(e-)　generated　by　immobilized　nanomaterials　could　effectively　remove　pollutants　under　visible　light　irradiation.　This　photocatalytic　MD　system　provides　an　attractive　avenue　for　the　water　reclamation　from　s-VOCs　contaminated　wastewater　in　the　practical　applications.　©　2022　Elsevier　B.V.