Functional　variants　of　immune-related　genes　may　be　implicated　in　the　occurrence　of　colorectal　cancer　(CRC).　In　this　study,　Programmed　cell　death　(PDCD)-1.6　(rs10204525　T/C),　PDCD-1.7　(rs7421861　A/G),　and　PDCD-1.9　(rs2227982　A/G)　loci　were　selected　to　explore　gene　expression　and　the　potential　susceptibility　to　the　development　of　CRC.　Here,　1,003　CRC　patients　and　1,303　controls　were　included　and　three　PDCD-1　tagging　loci　were　selected　and　analyzed　by　using　SNPscan　genotyping　assays.　SHESIS　software　was　harnessed　to　obtain　the　haplotypes　of　the　PDCD-1　gene.　We　found　that　the　genotype　and　allele　distribution　of　PDCD-1　tagging　loci　did　not　significantly　affect　the　risk　of　CRC.　Adjustment　for　body　mass　index,　age,　smoking,　alcohol　using　and　sex　also　found　that　PDCD-1　tagging　loci　did　not　influence　the　occurrence　of　CRC.　In　conclusion,　this　study　suggests　that　the　PDCD-1　tagging　loci　(rs10204525,　rs7421861,　and　rs2227982)　are　not　correlated　with　CRC　susceptibility.