Light-responsive　drug　delivery　systems　(DDS)　exhibit　the　advantages　of　non-invasive,　high　controllability　and　spatio-temporal　precision.　However,　DDS　triggered　by　near-infrared　(NIR)　light　are　few　and　inefficient.　In　this　work,　we　designed　a　novel　NIR-responsive　upconversion　nanoplatform　for　drug　delivery.　In　this　nanoplatform,　core-shell　upconversion　nanoparticle　(UCNP)　NaYF4:Yb,Er@NaYF4　was　coated　by　mesoporous　silica,　and　then　successively　coupled　with　NIR　dye　cypate,　amantadine　(AD)　and　beta-cyclodextrin　(beta-CD)　to　block　the　pores　and　entrap　the　drugs.　The　cypate　molecules　with　the　feature　of　auto-sensitized　photooxidation　under　808　nm　irradiation　were,　for　the　first　time,　employed　as　light-responsive　moieties　in　DDS.　The　obtained　nanoplatform　was　characterized　by　transmission　electron　microscopy　(TEM),　X-ray　diffraction　(XRD),　N-2　adsorption/desorption,　dynamic　light　scattering　(DLS)　and　zeta　potential　analysis.　Mechanism　of　photocleavage　of　cypate　by　singlet　oxygen　(O-1(2))　was　also　investigated　by　electron　spin　resonance　(ESR)　measurement.　The　nanoplatform　loaded　with　antibiotic　ofloxacin　(OFL)　showed　a　low　drug　leakage　(6.9%)　in　the　dark　condition　and　a　rapid　release　(50.9%)　upon　808　nm　irradiation　with　a　relatively　low　power　density　of　0.5　W.cm(-2)　for　40　min.　Moreover,　on-demand　release　of　OFL　can　be　achieved　by　adjusting　the　irradiation　time　(0　similar　to　40　min).　In　vitro　antibacterial　experiments　showed　that　the　nanoplatform　had　a　much　better　antibacterial　effect　against　Staphylococcus　aureus　after　808　nm　irradiation　as　compared　with　the　group　without　irradiation.　These　results　further　verified　the　excellent　NIR-responsive　performance　for　the　designed　nanoplatform.　In　addition,　the　nanoplatform　exhibited　strong　and　stable　upconversion　luminescence　(UCL)　under　980　nm　excitation,　which　can　be　applied　for　DDS　tracing　and　bioimaging.　The　cytocompatibility　of　the　nanoplatform　was　evaluated　by　methyl　thiazolyl　tetrazolium　(MTT)　assay,　showing　that　the　nanoplatform　had　no　cytotoxic　effect　on　human　embryonic　liver　cell　line　(LO2)　and　exhibited　great　potentials　in　versatile　bioapplications.　Our　work　may　open　up　a　new　avenue　for　the　exploration　of　multi-functional　NIR-responsive　DDS.