In　this　study,　tamarind　polysaccharide　gum　was　first　used　in　the　sulfidization　flotation　of　azurite　to　improve　the　Cu　grade　of　the　concentrate　via　the　depression　of　talc.　The　flotation　and　contact　angle　test　results　indicated　that　the　hydrophobicity　and　floatability　of　talc　were　weakened,　and　the　recovery　decreased　with　the　addition　of　tamarind　polysaccharide　gum,　but　the　flotation　behavior　of　azurite　was　barely　influenced.　At　pH　8.0,　using　30　mg/L　tamarind　polysaccharide　gum　with　200　mg/L　Na2S　and　400　mg/L　NaBX　to　separate　azurite　and　talc,　the　recoveries　of　which　were　80.42%　and　18.07%,　respectively.　To　explore　the　adsorption　mechanism　of　tamarind　polysaccharide　gum,　zeta　potential　measurements,　X-ray　photoelectron　spectroscopy　and　Fourier　transform　infrared　spectroscopy　analyses　were　conducted.　The　results　indicated　that　tamarind　polysaccharide　gum　selectively　adsorbed　on　the　talc　surface,　thus　the　flotation　separation　of　azurite　and　talc　was　achieved,　and　the　concentrate　grade　in　the　sulfidization　flotation　of　azurite　was　increased.　©　2022　Elsevier　Ltd