Mechanics-based　macro-models　are　often　used　to　simulate　the　cyclic　response　of　infilled　reinforced　concrete　(RC)　frames.　However,　these　approaches　are　affected　by　uncertainties　regarding　damage　and　failure　mechanisms.　Therefore,　this　contribution　proposes　a　new　smooth　data-driven　model　for　the　hysteresis　of　infilled　RC　frames.　The　infill　panel　is　modeled　through　a　damage-based　Bouc-Wen　element,　which　accounts　for　both　pinching　and　deterioration　of　the　mechanical　characteristics.　The　parameters　of　the　model　are　calibrated　from　an　experimental　data　set　of　cyclic　responses　of　RC　infilled　frames.　Analytical　correlations　between　parameters　and　geometric　and　mechanical　characteristics　of　the　infilled　frame　are　derived.　Blind　validation　tests　are　carried　out　in　order　to　demonstrate　the　effectiveness　of　the　proposed　model.　©　2021　COMPDYN　Proceedings.