Silicate　bioglass　is　of　great　importance　in　bone　engineering　because　of　its　excellent　bioactivity　and　osteogenic　effects.　In　this　study,　hydroxyapatite-like　bioactive　glass　based　on　the　xSiO2-CaO-P2O5　(x　=　30,　45,　60　and　90　mol.%,　Ca/P　=　1.67)　system　was　synthesized　by　the　sol-gel　method,　and　the　corresponding　structural　evolution,　apatite-forming　ability　and　cytotoxicity　were　systematically　investigated.　The　results　suggest　that　both　a　higher　heat　treatment　temperature　and　a　lower　SiO2　content　increase　the　crystallinity　tendency　of　the　bioglass,　and　the　samples　become　obviously　compact　as　the　SiO2　amount　increases　from　30　to　90　mol.%.　Compared　with　the　samples　with　higher　SiO2　content,　the　30Si　sample　shows　more　remarkable　internal　connected　mesoporous　structures,　with　a　higher　specific　surface　area　up　to　129.12　m2/g,　exhibiting　excellent　hydroxyapatite　formation　in　simulated　body　fluid.　Moreover,　no　obvious　inhibitory　effect　was　presented　on　human　periodontal　ligament　cells　(hPDLCs)　for　any　of　the　silicate　glass　samples.　©　2021　Elsevier　Ltd　and　Techna　Group　S.r.l.