At　present,　processing　substantial　livestock　excreta　produced　by　numerous　concentrated　small–middle-type　livestock　farms　(SMLFs)　has　been　a　major　problem　of　livestock　farm　owners　and　government　departments.　To　solve　this　problem,　this　study　established　a　suitability　evaluation　system　for　the　spatial　layout　of　a　centralized　treatment　center　of　livestock　excreta　(CTCLE).　On　this　basis,　combined　with　the　collection　points　of　livestock　excreta　(CPLEs)　determined　by　spatial　clustering　algorithm　and　median　center　and　matched　farmlands,　the　spatial　site　selection　of　CTCLE　was　analyzed　using　the　geographic　information　system　(GIS)　spatial　analysis　method　and　GIS　component　development　technology.　Practical　application　research　was　conducted　in　Nantong　Town,　and　pigs　were　used　as　examples.　Results　showed　that　most　regions　of　Nantong　Town　belong　to　forbidden　and　unsuitable　regions,　accounting　for　68.63%　of　the　total　region　of　the　town.　A　small　part　of　a　highly　suitable　region　(6.428　ha)　was　determined　as　potential　CTCLE.　A　total　of　839　SMLFs　were　divided　into　61　CPLEs,　and　the　spatial　relation　between　potential　CTCLEs　and　farmlands　was　established.　The　spatial　sites　of　11　CTCLEs　in　Nantong　Town,　Minhou　County　were　selected,　and　the　total　nitrogen　and　phosphorus　of　livestock　excreta　to　be　reduced　were　estimated.　The　results　will　provide　a　scientific　basis　for　the　utilization　of　livestock　excreta　and　the　spatial　layout　planning　of　livestock　and　poultry　breeding.　©　2020　Elsevier　B.V.