Transportation　of　Carbon　Dioxide　(CO2)　is　an　essential　part　of　Carbon　Capture　and　Storage　(CCS)　chain.　Transportation　using　pipelines　is　known　as　one　of　the　most　economical　ways　for　large-quantity　of　CO2.　In　CCS　projects,　it　is　very　important　to　ensure　the　safe　operation　of　the　CO2　pipelines.　Thus　in　the　design　stage,　the　risk　associated　with　CO2　pipelines　should　be　identified.　This　paper　reports　a　method　of　Quantitative　Risk　Assessment　(QRA)　for　the　possible　release　of　supercritical　CO2　(scCO2)　pipelines,　including　the　individual　risk　and　social　risk.　In　this　method,　the　data　of　failure　frequency　was　summarized　and　the　failure　frequency　suitable　for　CO2　pipelines　was　modified　based　on　the　effect　of　third-party　activities.　Furthermore,　the　fatal　length　was　introduced　to　describe　the　integrated　fatality　along　the　pipeline.　A　two-phase　model　for　CO2　release　and　a　modified　Gaussian　plume　model　for　CO2　dispersion　were　used　to　obtain　the　release　consequences　in　CO2　pipeline　QRAs　for　the　first　time.　The　results　show　that　the　modified　failure　frequencies　of　a　full-bore　rupture　and　a　puncture　are　both　2.32　×　10−4　km−1　year−1.　To　demonstrate　the　method,　a　QRA　case　based　on　a　hypothetical　accident　release　of　a　scCO2　pipeline　was　presented.　The　QRA　model　proposed　provides　a　potential　framework　to　determine　the　safe　distance　of　CO2　pipelines.　©　2021