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author：

Yu, Shujuan (Yu, Shujuan.) [1] | Sun, Gaohui (Sun, Gaohui.) [2] | Sui, Yaqun (Sui, Yaqun.) [3] | Li, Hanlin (Li, Hanlin.) [4] | Mai, Yuhan (Mai, Yuhan.) [5] | Wang, Guodong (Wang, Guodong.) [6] | Zhang, Ning (Zhang, Ning.) [7] | Bi, Yuhai (Bi, Yuhai.) [8] | Gao, George F. (Gao, George F..) [9] | Xu, Peng (Xu, Peng.) [10] | Jiang, Longguang (Jiang, Longguang.) [11] | Yuan, Cai (Yuan, Cai.) [12] | Yang, Yang (Yang, Yang.) [13] | Huang, Mingdong (Huang, Mingdong.) [14]

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EI

Abstract：

The　ongoing　pandemic　of　coronavirus　disease　2019　(COVID-19)　posed　a　major　challenge　to　the　public　health.　Currently,　no　proven　antiviral　treatment　for　Severe　Acute　Respiratory　Syndrome　Coronavirus　2　(SARS-CoV-2)　infection　is　available.　Here　we　report　compounds　pentalysine　β-carbonylphthalocyanine　zinc　(ZnPc5K)　and　chlorin　e6　(ce6)　potently　inhibited　the　viral　infection　and　replication　in　vitro　with　EC50　values　at　nanomolar　level.　These　compounds　were　first　identified　by　screening　a　panel　of　photosensitizers　for　photodynamic　viral　inactivation.　Such　viral　inactivation　strategy　is　implementable,　and　has　unique　advantages,　including　resistance　to　virus　mutations,　affordability　compared　to　the　monoclonal　antibodies,　and　lack　of　long-term　toxicity.　©　2021

Keyword：

Diagnosis Diseases Monoclonal antibodies Photosensitizers Viruses

Community：

  • [ 1 ] [Yu, Shujuan]College of Chemistry, Fuzhou University, Fujian; 350108, China
  • [ 2 ] [Sun, Gaohui]College of Chemistry, Fuzhou University, Fujian; 350108, China
  • [ 3 ] [Sui, Yaqun]College of Chemistry, Fuzhou University, Fujian; 350108, China
  • [ 4 ] [Li, Hanlin]College of Chemistry, Fuzhou University, Fujian; 350108, China
  • [ 5 ] [Mai, Yuhan]College of Chemistry, Fuzhou University, Fujian; 350108, China
  • [ 6 ] [Wang, Guodong]College of Chemistry, Fuzhou University, Fujian; 350108, China
  • [ 7 ] [Zhang, Ning]CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing; 100101, China
  • [ 8 ] [Bi, Yuhai]CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing; 100101, China
  • [ 9 ] [Bi, Yuhai]University of Chinese Academy of Sciences, Beijing; 101408, China
  • [ 10 ] [Gao, George F.]CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing; 100101, China
  • [ 11 ] [Gao, George F.]University of Chinese Academy of Sciences, Beijing; 101408, China
  • [ 12 ] [Xu, Peng]College of Biological Science and Engineering, Fuzhou University, Fuzhou; Fujian; 350108, China
  • [ 13 ] [Jiang, Longguang]College of Chemistry, Fuzhou University, Fujian; 350108, China
  • [ 14 ] [Yuan, Cai]College of Biological Science and Engineering, Fuzhou University, Fuzhou; Fujian; 350108, China
  • [ 15 ] [Yang, Yang]Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China
  • [ 16 ] [Huang, Mingdong]College of Chemistry, Fuzhou University, Fujian; 350108, China

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Dyes and Pigments

ISSN： 0143-7208

Year： 2021

Volume： 194

5 . 1 2 2

JCR@2021

4 . 1 0 0

JCR@2023

ESI HC Threshold：117

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 2

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