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author：

Zhang, Da (Zhang, Da.) [1] | Lin, Ziguo (Lin, Ziguo.) [2] | Wu, Ming (Wu, Ming.) [3] | Cai, Zhixiong (Cai, Zhixiong.) [4] | Zheng, Youshi (Zheng, Youshi.) [5] | He, Lei (He, Lei.) [6] | Li, Zhenli (Li, Zhenli.) [7] | Zhou, Jie (Zhou, Jie.) [8] | Sun, Liqin (Sun, Liqin.) [9] | Chen, Geng (Chen, Geng.) [10] | Zeng, Yongyi (Zeng, Yongyi.) [11] | Li, Juan (Li, Juan.) [12] | Liu, Jingfeng (Liu, Jingfeng.) [13] | Yang, Huanghao (Yang, Huanghao.) [14] | Liu, Xiaolong (Liu, Xiaolong.) [15]

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EI

Abstract：

Although　tumor-specific　neoantigen-based　cancer　vaccines　hold　tremendous　potential,　it　still　faces　low　cross-presentation　associated　with　severe　degradation　via　endocytosis　pathway.　Herein,　a　thiolated　nano-vaccine　allowing　direct　cytosolic　delivery　of　neoantigen　and　Toll　like　receptor　9　agonist　CpG-ODN　is　developed.　This　approach　is　capable　of　bypassing　the　endo-/lysosome　degradation,　increasing　uptake　and　local　concentration　of　neoantigen　and　CpG-ODN　to　activate　antigen-presenting　cells,　significantly　strengthening　the　anti-cancer　T-cell　immunity.　In　vivo　immunization　with　thiolated　nano-vaccine　enhanced　the　lymph　organ　homing　and　promoted　the　antigen　presentation　on　dendritic　cells,　effectively　inhibited　tumor　growth,　and　significantly　prolonged　the　survival　of　H22-bearing　mice.　Strikingly,　further　combination　of　the　thiolated　nano-vaccine　with　anti-programmed　cell　death　protein-1　antibody　(αPD-1)　could　efficiently　reverse　immunosuppression　and　enhance　response　rate　of　tumors,　which　led　to　enhanced　tumor　elimination,　complete　prevention　of　tumor　re-challenge,　and　long-term　survival　above　150　d.　Collectively,　a　versatile　methodology　to　design　cancer　vaccines　for　strengthening　anti-cancer　T-cell　immunity　in　solid　tumors　is　presented,　which　could　be　further　remarkably　enhanced　by　combining　with　immune　checkpoint　inhibitors.　©　2021　The　Authors.　Advanced　Science　published　by　Wiley-VCH　GmbH

Keyword：

Antigens Cell death Collector efficiency Diseases Mammals Molecular biology T-cells Tumors Vaccines

Community：

  • [ 1 ] [Zhang, Da]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
  • [ 2 ] [Zhang, Da]The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou; 350002, China
  • [ 3 ] [Lin, Ziguo]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
  • [ 4 ] [Wu, Ming]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
  • [ 5 ] [Wu, Ming]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
  • [ 6 ] [Cai, Zhixiong]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
  • [ 7 ] [Cai, Zhixiong]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
  • [ 8 ] [Zheng, Youshi]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
  • [ 9 ] [Zheng, Youshi]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
  • [ 10 ] [He, Lei]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
  • [ 11 ] [He, Lei]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
  • [ 12 ] [Li, Zhenli]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
  • [ 13 ] [Li, Zhenli]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
  • [ 14 ] [Zhou, Jie]The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou; 350002, China
  • [ 15 ] [Sun, Liqin]The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou; 350002, China
  • [ 16 ] [Chen, Geng]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
  • [ 17 ] [Chen, Geng]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
  • [ 18 ] [Zeng, Yongyi]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
  • [ 19 ] [Zeng, Yongyi]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
  • [ 20 ] [Li, Juan]The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou; 350002, China
  • [ 21 ] [Liu, Jingfeng]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
  • [ 22 ] [Liu, Jingfeng]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
  • [ 23 ] [Liu, Jingfeng]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou; 350002, China
  • [ 24 ] [Yang, Huanghao]The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou; 350002, China
  • [ 25 ] [Liu, Xiaolong]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
  • [ 26 ] [Liu, Xiaolong]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
  • [ 27 ] [Liu, Xiaolong]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou; 350002, China

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Advanced Science

Year： 2021

Issue： 6

Volume： 8

1 7 . 5 2 1

JCR@2021

1 4 . 3 0 0

JCR@2023

ESI HC Threshold：87

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 0

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