Photodynamic　therapy　(PDT)　is　a　promising　treatment　for　cancers　such　as　superficial　skin　cancers,　esophageal　cancer,　and　cervical　cancer.　Unfortunately,　PDT　often　does　not　have　sufficient　therapeutic　benefits　due　to　its　intrinsic　oxygen　dependence　and　the　limited　permeability　of　irradiating　light.　Side　effects　from　＇always　on＇　photosensitizers　(PSs)　can　be　problematic,　and　PDT　cannot　treat　tumor　metastases　or　recurrences.　In　recent　years,　supramolecular　approaches　using　non-covalent　interactions　have　attracted　attention　due　to　their　potential　in　PS　development.　A　supramolecular　PS　assembly　could　be　built　to　maximize　photodynamic　effects　and　minimize　side　effects.　A　combination　of　two　or　more　therapies　can　effectively　address　shortcomings　while　maximizing　the　benefits　of　each　treatment　regimen.　Using　the　supramolecular　assembly,　it　is　possible　to　design　a　multifunctional　supramolecular　PS　to　exert　synergistic　effects　by　combining　PDT　with　other　treatment　methods.　This　review　provides　a　summary　of　important　research　progress　on　supramolecular　systems　that　can　be　used　to　combine　PDT　with　photothermal　therapy,　chemotherapy,　and　immunotherapy　to　compensate　for　the　shortcomings　of　PDT,　and　it　provides　an　overview　of　the　prospects　for　future　cancer　treatment　advances　and　clinical　applications.　©　The　Royal　Society　of　Chemistry　2021.