Biofilms　formed　on　urinary　catheters　remain　a　major　headache　in　the　modern　healthcare　system.　Among　the　various　kinds　of　biocide-releasing　urinary　catheters　that　have　been　developed　to　prevent　biofilm　formation,　Ag　nanoparticles　(AgNPs)-coated　catheters　are　of　great　promising　potential.　However,　the　deposition　of　AgNPs　on　the　surface　of　catheters　suffers　from　several　inherent　shortcomings,　such　as　damage　to　the　urethral　mucosa,　uncontrollable　Ag　ion　kinetics,　and　unexpected　systematic　toxicity.　Here,　AgNPs-decorated　amphiphilic　carbonaceous　particles　(ACPs@AgNPs)　with　commendable　dispersity　in　solvents　of　different　polarities　and　broad-spectrum　antibacterial　activity　are　first　prepared.　The　resulting　ACPs@AgNPs　exert　good　compatibility　with　silicone　rubber,　which　enables　the　easy　fabrication　of　urinary　catheters　using　a　laboratory-made　mold.　Therefore,　ACPs@AgNPs　not　only　endow　the　urinary　catheter　with　forceful　biocidal　activity　but　also　improve　its　mechanical　properties　and　surface　wettability.　Hence,　the　designed　urinary　catheter　possesses　excellent　capacity　to　resist　bacterial　adhesion　and　biofilm　formation　both　in　vitro　and　in　an　in　vivo　rabbit　model.　Specifically,　a　long-term　antibacterial　study　highlights　its　sustainable　antibacterial　activity.　Of　note,　no　obvious　toxicity　or　inflammation　in　rabbits　was　triggered　by　the　designed　urinary　catheter　in　vivo.　Overall,　the　hybrid　urinary　catheter　may　serve　as　a　promising　biocide-releasing　urinary　catheter　for　antibacterial　and　antibiofilm　applications.　©　2021　American　Chemical　Society.