Two　new　tungsten　oxide　clusters　compounds　on　Na1,　and　through　the　OW16···O7　(2.988Å)　hydrogen　bond　connect　into　a　three-dimensional　network　structure.　We　conducted　infrared　tests,　thermogravimetric　tests　and　two-dimensional　infrared　correlation　spectroscopy　tests　on　compounds　1　and　2,　and　set　up　control　experiments　to　test　the　inhibitory　effects　of　two　compounds　on　two　common　pathogenic　bacteria　E.　coli　and　Staphylococcus　aureus　in　life,　combined　with　two-dimensional　infrared　correlation　spectroscopy　(2D-IR　COS)　and　thermogravimetric　analysis,　the　sandwich-type　compound　1　and　compound　2　with　the　same　configuration,　the　polarizability　of　Mn　and　Cu　have　a　greater　impact　on　the　overall　configuration,　which　may　be　directly　lead　to　the　different　antibacterial　effects　of　the　both.　Experimental　tests　and　analysis　show　that　the　transition　metals　in　the　compound　have　a　close　influence　on　the　inhibition　of　S.　aureus.　©　2021　Elsevier　B.V.