Abalone　is　a　precious　food　and　abalone　shell　can　also　be　used　as　an　ingredient　of　traditional　Chinese　medicine.　However,　large　numbers　of　abalone　shells　are　thrown　away　which　results　in　resource　waste　and　even　environmental　pollution.　We　have　prepared　an　injectable　natural　bioactivity　Abalone　shell/calcium　sulfate　composite　cement　scaffold.　Besides,　we　did　a　series　of　physiochemical,　cellular,　and　animal　tests.　All　results　display　that　the　scaffold　owns　good　mechanical　properties,　predominant　mineralization　and　controllable　degradation　properties.　Also,　the　cement　possesses　excellent　bioactivity,　it　can　promote　proliferation　and　differentiation　of　osteoblast　to　facilitate　bone　reconstruction.　Thus,　Abalone　shell/Calcium　sulfate　composite　cement　scaffold　would　provide　a　new　approach　for　both　abalone　high-value　utilization　and　the　clinical　irregular　bone　defects　rebuilding.　©　2021　Elsevier　B.V.