The　conductive　hydrogel　has　shown　extensive　applications　in　multifunctional　sensors.　However,　the　intrinsic　characteristics　of　conductive　hydrogels,　such　as　lacking　anti-freezing,　mechanical　strength,　and　being　easily　dehydrated　have　hindered　their　application　in　wearable　devices.　Herein,　reduced　graphene　oxide　(rGO)　and　graphene　oxide　(GO)　nanosheets　were　incorporated　into　a　porous　cross-linking　poly(vinyl　alcohol)　(PVA)　hydrogel　network　within　dimethyl　sulfoxide　(DMSO)/H2O　binary　solvent.　A　honeycomb-like　dense　micro-network　and　uniform　dispersion　conductive　tough　fillers　endow　high　toughness　(3.1　MPa　@　600%　strain)　and　conductivity　to　the　organohydrogel.　With　the　intense　interaction　between　water　and　DMSO,　the　organohydrogel　exhibits　reliable　mechanical　and　electronic　performance　in　a　wide　range　of　temperatures　(-30　to　60　°C)　and　possesses　excellent　ambient　stability.　The　organohydrogel　had　excellent　sensitivity　and　linear　repeatable　response　ability　in　both　mechanical　and　thermal　stimulation.　With　the　integrated　unique　features,　the　sensitive　organohydrogel　was　developed　for　a　multifunctional　sensor.　As　a　strain/pressure　sensor,　it　exhibited　a　sensitive　response　to　the　applied　tensile　or　compressed　strain　with　repeatability　and　durability.　As　a　temperature　sensor,　it　presented　excellent　linear　and　reliable　thermal　response　with　a　high　sensing　accuracy.　This　work　provides　a　new　paradigm　for　designing　a　wearable　multifunctional　sensor　or　E-skin,　which　is　used　to　detect　the　motion　or　temperature　of　the　human　in　the　future.　©　2021　The　Royal　Society　of　Chemistry.