Alkali　lignin　was　used　as　raw　material　to　prepare　alkali　lignin-based　activated　carbon　(LAC).　And　then,　lignin-based　activated　carbon-supported　with　nickel-zinc　oxides　(NiZn-DO/LAC)　was　fabricated　by　hydrothermal　synthesis　after　adding　nickel　nitrate　and　zinc　nitrate　onto　LAC.　The　structure　of　NiZn-DO/LAC　was　characterized　by　BET,　SEM　and　XRD,　and　the　adsorption　behavior　of　sulfathiazole　(ST)　in　aqueous　solution　was　also　studied.　The　results　showed　that　the　NiZn-DO/LAC　had　evident　obvious　three-dimensional　porous　structure　and　stable　crystal　structure　with　a　large　specific　surface　area　of　759.1m2/g.　In　the　process　of　ST　adsorption,　the　NiZn-Do/Lac　showed　excellent　adsorption　performance,　with　the　maximum　adsorption　capacity　up　to　328.2mg/g,　which　was　better　than　other　reported　adsorbents.　Additionally,　the　ST　was　easily　desorbed　from　NiZn-DO/LAC　with　NaOH　solution　and　the　analytical　rate　of　NiZn-DO/LAC　was　still　reach　up　to　79.43%　after　4times　of　recycles.　Furthermore,　it　showed　that　the　adsorption　behavior　of　ST　over　NiZn-DO/LAC　was　mainly　through　the　synergistic　effect　of　electrostatic　interaction,　π-π　interaction,　complexation,　hydrophobic　effects　and　hydrophobicity,　resulting　in　a　great　improvement　of　adsorption　performance.　©　2021,　Editorial　Board　of　China　Environmental　Science.　All　right　reserved.