Continuous　and　large-scale　production　of　phospholipids　stabilized　emulsions　and　nanoparticles　with　controllable　particle　size　and　stability　has　always　been　a　challenge.　Here,　we　use　flash　nano-precipitation　(FNP)　to　produce　lecithin　stabilized　α-tocopheryl　acetate　(Vitamin　E-acetate)　particles　at　a　production　rate　much　higher　than　conventional　batch　mixing　and　thin-film　hydration.　The　FNP　produces　particles　with　more　homogeneous　lecithin　coverage　comparing　to　conventional　slow　mixing.　As　determined　by　dynamic/electrophoretic　light　scattering,　transmission　electron　microscope　(TEM)　and　Quartz　Crystal　Microbalance　with　Dissipation　(QCM-D),　particles　with　low　percent　core　are　covered　by　thick　multiple　lecithin　layers　and　aggregate　easily　with　the　coalescence　of　lecithin　shell;　particles　with　medium　percent　core　content　are　covered　with　a　thin　layer　of　lecithin,　which　provides　a　high　enough　ζ-potential　to　stabilize　the　particle;　for　particles　with　percent　core　higher　than　95%,　the　large　spacing　between　lecithin　molecules　result　in　Ostwald　ripening　and　aggregation.　With　a　given　composition,　the　particle　size　and　stability　could　both　be　precisely　predicted　using　the　Smoluchowski＇s　diffusion　limited　particle　growth　model　and　the　Derjaguin-Landau,　Verwey-Overbeek　(DLVO)　theory.　This　work　demonstrates　that　the　compositions　affect　the　adsorption　of　phospholipid　molecules　at　the　particle　surface,　which　further　control　particle　size　and　stability.　©　2020　Elsevier　Ltd