The　quasi-static　tests　of　five　concrete　filled　steel　tube　(CFST)　reinforced　concrete　columns　with　hollow　box　section　(CFSTRC-HBS　columns　for　short)　and　one　CFST　lattice　column　were　conducted　to　investigate　the　effect　of　in-plane　limb　spacing　and　axial　compression　ratio　on　the　seismic　performance　of　CFSTRC-HBS　columns.　The　results　indicate　that　CFSTRC-HBS　columns　exhibit　pinch-shaped　load-displacement　hysteretic　curves　under　horizontal　reversed　loading　and　the　main　failure　modes　are　manifested　as　the　horizontal　cracks　of　outer　concrete　in　the　out-of-plane　direction,　the　diagonal　cracks　of　in-plane　concrete　web,　and　the　vertical　cracks　and　crushing　of　outer　concrete　at　the　column　bottom.　The　whole　loading　process　can　be　divided　into　elastic　stage,　repairable　stage,　stiffness　degradation　stage,　bearing　capacity　degradation　stage　and　residual　bearing　capacity　stage.　After　the　partial　outer　concrete　is　damaged　and　fails,　the　bearing　capacity　of　CFSTRC-HBS　columns　decreases　significantly,　but　the　CFST　lattice　skeleton　can　continue　to　resist　horizontal　load.　When　the　in-plane　limb　spacing　increases　from　500　mm　to　650　mm,　the　elastic　stiffness,　the　horizontal　bearing　capacity,　and　the　cumulative　energy　dissipation　increase　by　44.6%,　26.0%,　and　15.8%　respectively.　When　the　axial　compression　ratio　increases　from　0.10　to　0.20,　the　horizontal　bearing　capacity　and　the　cumulative　energy　dissipation　increase　by　33.7%　and　48.7%,　respectively.　Based　on　the　theoretical　analysis　of　the　stress　state　of　the　plastic　hinge　section　at　the　bottom　of　the　column,　the　calculation　method　of　the　horizontal　bearing　capacity　of　CFSTRC-HBS　columns　with　high　precision　is　proposed,　which　is　in　good　agreement　with　the　test　results.　©　2021,　Editorial　Office　of　Journal　of　Building　Structures.　All　right　reserved.