An　optimized　aerobic-based　treatment　method　that　effectively　removes　antibiotics　and　retains　ammonia　is　urgently　needed　for　the　field-return-based　management　of　livestock　wastewater.　Allylthiourea　(ATU,　used　for　BOD　determination),　and　2-chloro-6-trichloromethylpyridine　(TCMP)　and　3,4-dimethylpyrazole　phosphate　(DMPP)　(commonly　used　as　nitrogen　fertilizer　synergists)　were　separately　added　to　sequencing　batch　reactors　(SBRs),　in　order　to　investigate　their　effect　on　nitrification　inhibition　and　pollutant　removal　for　livestock　wastewater　treatment.　The　laboratory　test　shows　that　the　daily　addition　of　43.8　mg/L　ATU　or　17.5　mg/L　TCMP　to　SBRs　effectively　inhibited　nitrification.　Nitrification　inhibition　by　DMPP　seemed　fluctuated　and　insufficient　even　various　dosing　strategies　were　attempted.　The　removal　efficiency　of　antibiotics　was　reduced　from　95%　to　85%　with　the　addition　of　ATU,　while　not　significantly　influenced　by　TCMP　and　DMPP.　The　COD　removal　efficiency　was　reduced　by　only　6%-10%　with　the　addition　of　three　inhibitors.　The　pilot　study　shows　that　nitrification　inhibition　efficiency　reached　89%　with　the　daily　addition　of　11.5　mg/L　TCMP.　The　total　removal　efficiency　of　antibiotics　remained　over　93%.　The　laboratory　and　pilot　studies　consistently　demonstrate　that　TCMP　played　a　satisfactory　nitrification　inhibition　role　and　had　a　negligible　effect　on　antibiotic　removal.　The　current　work　provides　a　novel　insight　for　the　proper　field-return-based　management　of　livestock　wastewater,　which　achieves　the　dual　goals　of　reducing　the　risk　of　antibiotic　exposure　and　preserving　its　nutrient　value　as　fertilizers.　©　2021　Elsevier　B.V.