Thin　film　nanocomposite　(TFN)　polyamide　(PA)　membranes　has　drawn　increasing　attention　due　to　the　improved　physicochemical　properties　of　the　top　layer　for　versatile　separation　performance.　However,　the　commonly　used　fabrication　approach,　lacking　a　controllable　loading　of　nanofillers,　leads　to　a　random　and　insufficient　distribution　of　nanofillers　into　the　PA　layer　and　generates　interfacial　defects　that　deteriorate　the　membrane　performance.　Herein,　a　rational　strategy　for　incorporating　metal-organic　frameworks　(i.e.,　ZIF-8)　into　the　PA　layer　via　electrophoretic　deposition　(EPD)　was　proposed.　Driven　by　an　external　direct　current　field,　the　ZIF-8　nanoparticles　were　uniformly　assembled　onto　a　porous　ultrafiltration　(UF)　substrate　for　fabrication　of　high-performance　TFN　nanofiltration　membranes　by　vacuum-assisted　interfacial　polymerization　(IP).　The　resultant　TFN　nanofiltration　membrane　yielded　an　enhanced　water　permeability　of　22.4　+/-　1.2　L　center　dot　m-　2　center　dot　h-1　center　dot　bar-　1,　due　to　incorporation　of　ZIF-8　nanoparticles　which　created　extra　nano-channels　for　fast　water　permeation.　Additionally,　such　an　EPD　process　effectively　tailored　the　membrane　surface　properties　(e.g.,　zeta　potential)　and　conferred　a　considerably　high　rejection　for　Na2SO4　(96.9　+/-　0.7%)　but　a　low　rejection　for　NaCl　(18.9　+/-　2.5%),　demonstrating　an　excellent　selectivity　between　SO42-　and　Cl-　ions.　This　study　highlights　the　impressive　efficacy　of　the　EPD　process　in　precisely　anchoring　nanomaterials　to　design　high-performance　TFN　nanofiltration　membranes　for　target　separations.