Garsubellin　A　is　a　meroterpene　capable　of　enhancing　the　enzyme　choline　acetyltransferase　whose　decreased　level　is　believed　to　play　a　central　role　in　the　symptoms　of　Alzheimer＇s　disease.　Due　to　the　potentially　useful　biological　activity　together　with　the　novel　bridged　and　fused　cyclic　molecular　architecture,　garsubellin　A　has　garnered　substantial　synthetic　interest,　but　its　absolute　stereostructure　has　been　undetermined.　We　report　here　the　first　enantioselective　total　synthesis　of　(+)-garsubellin　A.　Our　synthesis　relies　on　stereoselective　fashioning　of　a　cyclohexanone　framework　and　double　conjugate　addition　of　1,2-ethanedithiol　that　promotes　aldol　cyclization　to　build　the　bicyclic　[3.3.1]　skeleton.　The　twelve-step,　protecting　group-free　synthetic　route　has　enabled　the　syntheses　of　both　the　natural　(-)-garsubellin　A　and　its　unnatural　(+)-antipode　for　biological　evaluations.