Photothermal　therapy　(PTT)　has　emerged　as　a　promising　therapeutic　approach　for　tumor　control　and　ablation.　Attention　has　focused　on　exploring　advanced　organic　photothermal　agents　(OPTAs),　with　advantages　of　easy　modification,　adjustable　photophysical　and　photochemical　properties,　good　compatibility,　and　inherent　biodegradability.　However,　few　detailed　studies　on　how　to　maximally　channelize　nonradiative　heat　generation　from　the　viewpoint　of　the　photothermal　conversion　mechanism　have　been　reported.　Thus,　here　we　assimilate　and　elaborate　on　several　available　action　mechanisms　to　maximize　the　photothermal　conversion　efficiency　(PCE)　of　organic　dyes.　Moreover,　we　also　propose　several　potential　challenges　that　require　substantial　future　work　to　address.