The　complex　physical　and　chemical　reactions　between　the　large　number　of　low-energy　(0-30　eV)　electrons　(LEEs)　released　by　high　energy　radiation　interacting　with　genetic　material　can　lead　to　the　formation　of　various　DNA　lesions　such　as　crosslinks,　single　strand　breaks,　base　modifications,　and　cleavage,　as　well　as　double　strand　breaks　and　other　cluster　damages.　When　crosslinks　and　cluster　damages　cannot　be　repaired　by　the　cell,　they　can　cause　genetic　loss　of　information,　mutations,　apoptosis,　and　promote　genomic　instability.　Through　the　efforts　of　many　research　groups　in　the　past　two　decades,　the　study　of　the　interaction　between　LEEs　and　DNA　under　different　experimental　conditions　has　unveiled　some　of　the　main　mechanisms　responsible　for　these　damages.　In　the　present　review,　we　focus　on　experimental　investigations　in　the　condensed　phase　that　range　from　fundamental　DNA　constituents　to　oligonucleotides,　synthetic　duplex　DNA,　and　bacterial　(i.e.,　plasmid)　DNA.　These　targets　were　irradiated　either　with　LEEs　from　a　monoenergetic-electron　or　photoelectron　source,　as　sub-monolayer,　monolayer,　or　multilayer　films　and　within　clusters　or　water　solutions.　Each　type　of　experiment　is　briefly　described,　and　the　observed　DNA　damages　are　reported,　along　with　the　proposed　mechanisms.　Defining　the　role　of　LEEs　within　the　sequence　of　events　leading　to　radiobiological　lesions　contributes　to　our　understanding　of　the　action　of　radiation　on　living　organisms,　over　a　wide　range　of　initial　radiation　energies.　Applications　of　the　interaction　of　LEEs　with　DNA　to　radiotherapy　are　briefly　summarized.