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author:

Lin, Weiming (Lin, Weiming.) [1] | Gao, Qinquan (Gao, Qinquan.) [2] (Scholars:高钦泉) | Du, Min (Du, Min.) [3] | Chen, Weisheng (Chen, Weisheng.) [4] | Tong, Tong (Tong, Tong.) [5] (Scholars:童同)

Indexed by:

EI SCIE

Abstract:

Alzheimer's disease (AD) is a progressive neurodegenerative disease, and mild cognitive impairment (MCI) is a transitional stage between normal control (NC) and AD. A multiclass classification of AD is a difficult task because there are multiple similarities between neighboring groups. The performance of classification can be improved by using multimodal data, but the improvement could be limited with inefficient fusion of multimodal data. This study aims to develop a framework for AD multiclass diagnosis with a linear discriminant analysis (LDA) scoring method to fuse multimodal data more efficiently. Magnetic resonance imaging, positron emission tomography, cerebrospinal fluid biomarkers, and genetic features were first preprocessed by performing age correction, feature selection, and feature reduction. Then, they were individually scored using LDA, and the scores that represent the AD pathological progress in different modalities were obtained. Finally, an extreme learning machine-based decision tree was established to perform multiclass diagnosis using these scores. The experiments were conducted on the AD Neuroimaging Initiative dataset, and accuracies of 66.7% and 57.3% and F1-scores of 64.9% and 55.7% were achieved in three- and four-way classifications, respectively. The results also showed that the proposed framework achieved a better performance than the method that did not score multimodal data and the methods in previous studies, thereby indicating that the LDA scoring strategy is an efficient way for multimodalities fusion in AD multiclass classification.

Keyword:

Alzheimer's disease Extreme learning machine Linear discriminant analysis Mild cognitive impairment Multiclass Multimodal

Community:

  • [ 1 ] [Lin, Weiming]Xiamen Univ Technol, Sch Optoelect & Commun Engn, Xiamen 361024, Peoples R China
  • [ 2 ] [Lin, Weiming]Xiamen Univ Technol, Fujian Key Lab Commun Network & Informat Proc, Xiamen 361024, Peoples R China
  • [ 3 ] [Gao, Qinquan]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350116, Peoples R China
  • [ 4 ] [Du, Min]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350116, Peoples R China
  • [ 5 ] [Tong, Tong]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350116, Peoples R China
  • [ 6 ] [Gao, Qinquan]Imperial Vis Technol, Fuzhou 350001, Peoples R China
  • [ 7 ] [Du, Min]Wuyi Univ, Fujian Prov Key Lab Eco Ind Green Technol, Wuyishan 354300, Peoples R China
  • [ 8 ] [Chen, Weisheng]Fujian Canc Hosp, Dept Thorac Surg, Fuzhou 350001, Peoples R China
  • [ 9 ] [Tong, Tong]Fuzhou Univ, Fujian Key Lab Med Instrumentat & Pharmaceut Tech, Fuzhou 350116, Peoples R China

Reprint 's Address:

  • 童同

    [Tong, Tong]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350116, Peoples R China

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Source :

COMPUTERS IN BIOLOGY AND MEDICINE

ISSN: 0010-4825

Year: 2021

Volume: 134

6 . 6 9 8

JCR@2021

7 . 0 0 0

JCR@2023

ESI Discipline: COMPUTER SCIENCE;

ESI HC Threshold:106

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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