The　reaction　of　MCM-41　with　tetramethyl　tin　was　studied　under　high　vacuum　condition,　and　the　composition,　structure　and　properties　of　the　resulted　solid　were　characterized　by　element　analysis,　gas　volumetry　analysis,　ICP,　XRD,　FTIR,　DRS　(diffuse　reflectance　spectroscopy),　13C　and　119Sn　MAS　NMR,　XPS,　BET,　TPD,　TPR,　adsorption　of　nitrogen　etc.,respectively.　The　results　showed　that　the　reaction　occurred　on　the　surface　without　destroying　the　framework　structure　of　the　zeolite,　leading　to　the　formation　of　the　monografted　species　(≡　Si-O)　SnMe3　for　MCM-41　at　773　K.　Grafting　methyltin　species　on　the　surface　resulted　in　decrease　of　the　pore　size　and　the　mesoporous　volume　of　MCM-41.　The　reaction　temperature　of　MCM-41　with　tetramethyl　tin　was　343　K　which　is　higher　than　that　of　HY　zeolite　with　tetramethyl　tin　(193　K)　and　SnMe3/MCM-41　is　thermal　stable　under　673　K　and　its　thermal　stability　is　higher　than　that　of　SnMe3/HY.