A　Schiff　base　ligand　4-[indol-3-yl]-but-3-en-2-one　benzoyl　hydrazone　(HL),　and　its　four　transition　metal　complexes　(ML2,　M=Cu(II),　Ni(II),　and　Co(II)　and　Co(II))　have　been　prepared　and　characterized　by　means　of　elemental　analysis,　EI-MS,　molar　conductivity,　IR,　UV-Vis　and　1H　NMR.　The　results　showed　that　HL　as　a　bidentate　ligand　coordinated　with　transition　metal　ions　to　form　four-coordination　complexes.　The　antibacterial　activity　was　studied　by　using　the　filter　scraps　diffusion　method,　and　the　results　indicated　that　the　ligand　and　the　complexes　had　a　low　bacteriostatic　activity　against　S.　Aureu,　P.　Aeruginosa　and　E.　Coli.　The　low　in　vitro　antitumor　activity　of　the　title　complexes　was　also　observed　by　using　MTT　method　against　KB,　A2780,　Bel7402　and　HELF.