Site-specifically cleavage of oxidized insulin B chain with Zn(II) ion studied by electrospray ionization mass spectrometry - Details

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author：

Jiang, J. (Jiang, J..) ^[1] | Mei, Y.H. (Mei, Y.H..) ^[2] | Zhu, L.G. (Zhu, L.G..) ^[3] | Wang, W.J. (Wang, W.J..) ^[4]

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Abstract：

The　electrospray　ionization　mass　spectrometry　and　tandem　mass　spectrometry　investigation　showed　that　the　binding　sites　of　Zn2+　with　oxidized　insulin　B　chain　are　His　5,　His　10,　and　Arg　22,　which　lead　to　the　selective　cleavages　of　the　peptide　bonds　at　Asn　3-Gln　4,　His　5-Leu　6,　Gly　8-Ser　9,　and　Glu　21-Arg　22　of　oxidized　insulin　B　chain.　©　2007　Jiang　Jiang.

Keyword：

Hydrolytic cleavage; Mass spectrometry; Oxidized insulin B chain; ZnCl2

Community：

[ 1 ] [Jiang, J.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 2 ] [Jiang, J.]College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China
[ 3 ] [Mei, Y.H.]State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, China
[ 4 ] [Zhu, L.G.]State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, China
[ 5 ] [Wang, W.J.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China

Reprint 's Address：

[Jiang, J.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China

Email：

fuzhoujiang_1969@yahoo.com.cn

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Source ：

Chinese Chemical Letters

ISSN： 1001-8417

Year： 2007

Issue： 5

Volume： 18

Page： 557-560

0 . 3 3 6

JCR@2007

9 . 4 0 0

JCR@2023

JCR Journal Grade：4

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 4

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 5

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