Sorbiterrin A, a novel sorbicillin derivative with cholinesterase inhibition activity from the marine-derived fungus Penicillium terrestre - Details

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Abstract：

A　novel　sorbicillinoid　named　sorbiterrin　A　(1),　possessing　an　unprecedented　skeleton　was　isolated　from　a　marine　sediment　derived　fungus　Penicillium　terrestre.　The　structure　including　absolute　stereochemistries　was　elucidated　by　analysis　of　NMR,　MS　data　and　TDDFT　CD　calculations.　Sorbiterrin　A　showed　moderate　acetylcholinesterase　(AChE)　inhibitory　effect　with　IC　50　25　μg/mL.　©　2011　Elsevier　Ltd.　All　rights　reserved.

Keyword：

Marine derived fungus; Penicillium terrestre; Sorbicillinoid

Community：

[ 1 ] [Chen, L.]Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China
[ 2 ] [Chen, L.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, 2 Xueyuan Road, Fuzhou, Fujian 350002, China
[ 3 ] [Zhu, T.]Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China
[ 4 ] [Ding, Y.]Department of Pharmacognosy, School of Pharmacy, University of Mississippi, MS 38677, United States
[ 5 ] [Khan, I.A.]Department of Pharmacognosy, School of Pharmacy, University of Mississippi, MS 38677, United States
[ 6 ] [Gu, Q.]Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China
[ 7 ] [Li, D.]Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China

Reprint 's Address：

[Khan, I.A.]Department of Pharmacognosy, School of Pharmacy, University of Mississippi, MS 38677, United States

Email：

ikhan@olemiss.edu

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Source ：

Tetrahedron Letters

ISSN： 0040-4039

Year： 2012

Issue： 3

Volume： 53

Page： 325-328

2 . 3 9 7

JCR@2012

1 . 5 0 0

JCR@2023

JCR Journal Grade：2

CAS Journal Grade：3

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WoS CC Cited Count：

SCOPUS Cited Count： 27

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Chinese Cited Count：

30 Days PV： 0

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