• Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

author:

May, R.K. (May, R.K..) [1] | Su, K. (Su, K..) [2] | Han, L. (Han, L..) [3] | Zhong, S. (Zhong, S..) [4] (Scholars:钟舜聪) | Elliott, J.A. (Elliott, J.A..) [5] | Gladden, L.F. (Gladden, L.F..) [6] | Evans, M. (Evans, M..) [7] | Shen, Y. (Shen, Y..) [8] | Zeitler, J.A. (Zeitler, J.A..) [9]

Indexed by:

Scopus

Abstract:

We present terahertz pulsed imaging (TPI) as a novel tool to quantify the hardness and surface density distribution of pharmaceutical tablets. Good agreement between the surface refractive index (SRI) measured by TPI and the crushing force measured from diametral compression tests was found using a set of tablets that were compacted at various compression forces. We also found a strong correlation between TPI results and tablet bulk density, and how these relate to tablet hardness. Numerical simulations of tablet surface density distribution by finite element analysis exhibit excellent agreement with the TPI measured SRI maps. These results show that TPI has an advantage over traditional diametral compression and is more suitable for nondestructive hardness and density distribution monitoring and control of pharmaceutical manufacturing processes. © 2013 Wiley Periodicals, Inc.

Keyword:

Compaction; Density distribution; Diametral compression test (DCT); Finite element analysis (FEA); Imaging methods; Mechanical properties; Processing; Tablet hardness testing; Tableting; Terahertz pulsed imaging (TPI)

Community:

  • [ 1 ] [May, R.K.]Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, United Kingdom
  • [ 2 ] [Su, K.]Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, United Kingdom
  • [ 3 ] [Han, L.]Department of Materials Science and Metallurgy, University of Cambridge, Cambridge CB2 3QZ, United Kingdom
  • [ 4 ] [Zhong, S.]Department of Electrical Engineering and Electronics, University of Liverpool, Liverpool L69 3GJ, United Kingdom
  • [ 5 ] [Zhong, S.]School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou City, China
  • [ 6 ] [Elliott, J.A.]Department of Materials Science and Metallurgy, University of Cambridge, Cambridge CB2 3QZ, United Kingdom
  • [ 7 ] [Gladden, L.F.]Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, United Kingdom
  • [ 8 ] [Evans, M.]TeraView Ltd., St John's Innovation Park, Cambridge, CB4 0WS, United Kingdom
  • [ 9 ] [Shen, Y.]Department of Electrical Engineering and Electronics, University of Liverpool, Liverpool L69 3GJ, United Kingdom
  • [ 10 ] [Zeitler, J.A.]Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, United Kingdom

Reprint 's Address:

  • [Zeitler, J.A.]Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, United Kingdom

Show more details

Related Keywords:

Related Article:

Source :

Journal of Pharmaceutical Sciences

ISSN: 0022-3549

Year: 2013

Issue: 7

Volume: 102

Page: 2179-2186

3 . 0 0 7

JCR@2013

3 . 7 0 0

JCR@2023

ESI Discipline: PHARMACOLOGY & TOXICOLOGY;

JCR Journal Grade:2

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 74

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

Online/Total:52/10044993
Address:FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code:350116) Contact Us:0591-22865326
Copyright:FZU Library Technical Support:Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1