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Abstract:
We present terahertz pulsed imaging (TPI) as a novel tool to quantify the hardness and surface density distribution of pharmaceutical tablets. Good agreement between the surface refractive index (SRI) measured by TPI and the crushing force measured from diametral compression tests was found using a set of tablets that were compacted at various compression forces. We also found a strong correlation between TPI results and tablet bulk density, and how these relate to tablet hardness. Numerical simulations of tablet surface density distribution by finite element analysis exhibit excellent agreement with the TPI measured SRI maps. These results show that TPI has an advantage over traditional diametral compression and is more suitable for nondestructive hardness and density distribution monitoring and control of pharmaceutical manufacturing processes. © 2013 Wiley Periodicals, Inc.
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Source :
Journal of Pharmaceutical Sciences
ISSN: 0022-3549
Year: 2013
Issue: 7
Volume: 102
Page: 2179-2186
3 . 0 0 7
JCR@2013
3 . 7 0 0
JCR@2023
ESI Discipline: PHARMACOLOGY & TOXICOLOGY;
JCR Journal Grade:2
CAS Journal Grade:3
Cited Count:
SCOPUS Cited Count: 74
ESI Highly Cited Papers on the List: 0 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 1
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