Magnetic graphene oxide-based electrochemiluminescent aptasensor for thrombin - Details

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Abstract：

A　new　electrochemiluminescence　(ECL)　reagent,　iridium(III)　complex　(Ir(III)　complex),　has　been　synthesized　and　applied　to　develop　an　ECL　biosensor　for　thrombin.　The　Ir(III)　complex　has　been　conjugated　to　aptamers　firstly　and　adsorbed　on　magneto-controlled　magnetic　graphene　oxide.　In　the　presence　of　the　target　(thrombin),　the　aptamers　will　release　into　solution　and　result　in　increased　ECL　intensity.　The　enhanced　ECL　intensity　has　a　direct　relationship　with　the　logarithm　of　thrombin　concentration　in　the　range　of　2.0　×　10　-9　to　5.0　×　10-8　mol/L.　The　detection　limit　was　1.3　×　10-9　mol/L　(S/N　=　3).　The　proposed　method　has　good　stability　and　reproducibility.　©　2012　Elsevier　Ltd.　All　Rights　Reserved.

Keyword：

Aptamer; Electrochemiluminescence (ECL); Iridium(III) complex; Magnetic graphene oxide; Thrombin

Community：

[ 1 ] [Jin, G.]Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Ministry of Education, Fuzhou, Fujian 350002, China
[ 2 ] [Lu, L.]Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Ministry of Education, Fuzhou, Fujian 350002, China
[ 3 ] [Gao, X.]Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Ministry of Education, Fuzhou, Fujian 350002, China
[ 4 ] [Li, M.-J.]Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Ministry of Education, Fuzhou, Fujian 350002, China
[ 5 ] [Qiu, B.]Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Ministry of Education, Fuzhou, Fujian 350002, China
[ 6 ] [Lin, Z.]Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Ministry of Education, Fuzhou, Fujian 350002, China
[ 7 ] [Yang, H.]Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Ministry of Education, Fuzhou, Fujian 350002, China
[ 8 ] [Chen, G.]Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Ministry of Education, Fuzhou, Fujian 350002, China

Reprint 's Address：

[Li, M.-J.]Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Ministry of Education, Fuzhou, Fujian 350002, China

Email：

mjli@fzu.edu.cn

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Source ：

Electrochimica Acta

ISSN： 0013-4686

Year： 2013

Volume： 89

Page： 13-17

4 . 0 8 6

JCR@2013

5 . 5 0 0

JCR@2023

JCR Journal Grade：1

CAS Journal Grade：2

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WoS CC Cited Count：

30 Days PV： 0

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