In　this　work,　Poly(methy　methacrylate-　styrene-　divinyl　benzene)　(MMA-S-DVB)　microspheres　were　prepared　by　suspension　polymerization　approach　in　the　presence　of　n-dodecane　as　porogenic　agent.　Various　types　of　measurements,such　as　binocular　biological　microscope　with　micrometer,　fourier　transform　infrared　(FT-IR)　and　N2　absorption　analysis　(BET)　were　conducted　to　characterize　the　MMA-S-DVB　microspheres.　The　effect　of　the　amount　of　surfactants　(PVA　and　NaCl),　porogenic　agent　and　crossing　agent(DVB)　on　the　morphology　of　microspheres　was　investigated　and　mass　ratio　of　oil/water　and　the　stirring　speed　were　also　discussed.　Finally,　according　to　the　experimental　results,the　optimum　experimental　condition　was　obtained　as　follow:　the　mass　ratio　of　S:MMA:DVB=3:3:4,　the　concentration　of　PVA　in　the　water　phase　is　2.2　wt　%,　the　concentration　of　NaCl　is　5　wt　%,　the　mass　ratio　of　oil/water　is　1:11,　the　stirring　speed　is　500rpm.Via　controlling　the　optimum　reaction　conditions　of　the　suspension　polymerization,　the　crosslinked　macroporous　resin　polymer　MMA-S-DVB　microspheres　with　excellent　sphericity　and　controllable　diameter　in　a　range　of　200~400　μm　can　be　gained.　©　(2013)　Trans　Tech　Publications,　Switzerland.