About　inter-enterprise　cooperation　and　innovation　in　industrial　clusters,　a　novel　knowledge　similarity　degree　based　on　grey　relational　analysis　is　proposed,　and　a　dynamic　evolution　model　of　innovation　network　is　proposed　considering　many　kinds　of　knowledge　elements　and　social　factors　of　the　main　innovation　agent　in　this　paper.　In　the　model,　the　intrinsic　relationship　of　knowledge　integration　and　innovation　network　structure　are　established　using　multi-agent　simulation　method.　The　simulation　results　show　that:　industrial　clusters　innovation　network　has　significantly　small　world;　enterprise　knowledge　integration　capabilities　and　innovation　cooperation　develop　Jointly.　As　the　cluster　network　size　increases,　knowledge　integration　capabilities　of　the　enterprises　are　improved,　networks　become　more　sparse,　the　number　of　inter-enterprise　cooperation　reduced.　Enterprises　should　actively　enhance　the　innovative　and　cooperative　relations　for　enhancing　the　knowledge　level　effectively,　especially　in　the　early　stage　of　cluster　development.