Photophysical　photochemical　properties,　in　vitro　photodynamic　anticancer　activity　and　interaction　with　albumin　of　a　new　axially　modified　silicon　phthalocyanine,　i.e.　di　(2-amino-6-trifluoromethyl-4-pyrimidinyloxy)　silicon　phthalocyanine　(SiPcF),　were　studied　in　the　present　paper.　The　Q　band　maximum　absorption　of　SiPcF　located　at　686　nm　with　the　molar　absorption　coefficient　of　2.3×105　mol-1·L·cm-1.　The　fluorescence　emission　of　SiPcF　peaked　at　694　nm　with　a　fluorescence　quantum　yield　of　0.46.　Its　singlet　oxygen　quantum　yield　produced　by　photosensitization　is　0.38,　suggesting　that　SiPcF　is　an　effective　1O2　photosensitizer.　There　is　strong　interaction　between　SiPcF　and　bovine　serum　albumin　(BSA).　The　binding　constant　is　4.33×105　mol·L-1　and　the　number　of　binding　sites　is　1.　In　vitro　experiments　show　that　SiPcF　had　a　high　photodynamic　anticancer　activity　against　human　hepatoma　cells　HepG2　with　an　IC50　value　down　to　5×10-7mol·L-1.