Synthesis, characterization, and DNA binding of a novel ligand and its Cu(II) complex - Details

author：

Li, M.-J. (Li, M.-J..) ^[1] | Lan, T.-Y. (Lan, T.-Y..) ^[2] | Lin, Z.-S. (Lin, Z.-S..) ^[3] | Yi, C. (Yi, C..) ^[4] | Chen, G.-N. (Chen, G.-N..) ^[5]

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Scopus

Abstract：

A　novel　naphthalene-2,3-diamine-2-salicylaldehyde　(NS)　ligand　and　its　mononuclear　copper(II)　complex　(CuNS)　have　been　synthesized　and　structurally　characterized.　The　UV-vis　absorption　and　emission　spectra　of　NS　showed　obvious　changes　on　addition　of　Cu2+　solution.　The　interaction　of　the　compounds　with　calf　thymus　DNA　and　G-quadruplex　DNA　were　investigated　by　spectroscopic　methods　and　thermal　melting　assay.　The　nucleolytic　cleavage　activity　of　the　compounds　was　investigated　on　double-stranded　circular　pBR322　plasmid　DNA　and　G-quadruplex　DNA　by　electrophoretic　mobility　shift　assay.　The　results　show　that　CuNS　has　a　greater　ability　to　stabilize　G-quadruplex　DNA　over　calf-thymus　DNA.　The　cytotoxicity　of　the　compounds　toward　HpeG2　cancer　cells　was　also　studied,　and　they　showed　significant　potential　for　antineoplastic　effects.　©　SBIC　2013.

Keyword：

Copper(II) complex; Cytotoxicity; DNA binding; Nucleolytic cleavage

Community：

[ 1 ] [Li, M.-J.]Department of Chemistry, Key Laboratory of Analysis and Detection Technology for Food Safety, Fuzhou University, Fuzhou 350108, China
[ 2 ] [Li, M.-J.]Beijing Synchrotron Radiation Laboratory, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100039, China
[ 3 ] [Lan, T.-Y.]Department of Chemistry, Key Laboratory of Analysis and Detection Technology for Food Safety, Fuzhou University, Fuzhou 350108, China
[ 4 ] [Lin, Z.-S.]Department of Chemistry, Key Laboratory of Analysis and Detection Technology for Food Safety, Fuzhou University, Fuzhou 350108, China
[ 5 ] [Yi, C.]School of Engineering, Sun Yat-Sen University, Guangzhou 510275, China
[ 6 ] [Chen, G.-N.]Department of Chemistry, Key Laboratory of Analysis and Detection Technology for Food Safety, Fuzhou University, Fuzhou 350108, China

Reprint 's Address：

[Li, M.-J.]Department of Chemistry, Key Laboratory of Analysis and Detection Technology for Food Safety, Fuzhou University, Fuzhou 350108, China

Email：

mjli@fzu.edu.cn

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Source ：

Journal of Biological Inorganic Chemistry

ISSN： 0949-8257

Year： 2013

Issue： 8

Volume： 18

Page： 993-1003

3 . 1 6 4

JCR@2013

2 . 7 0 0

JCR@2023

JCR Journal Grade：1

CAS Journal Grade：3

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 27

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

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