Preparation, characterization and MRI application of carboxymethyl dextran coated magnetic nanoparticles - Details

author：

Liu, G. (Liu, G..) ^[1] | Hong, R.Y. (Hong, R.Y..) ^[2] | Guo, L. (Guo, L..) ^[3] | Li, Y.G. (Li, Y.G..) ^[4] | Li, H.Z. (Li, H.Z..) ^[5]

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Abstract：

Superparamagnetic　nanoparticles　functionalized　with　carboxymethyl　dextran　(CM-dextran)　were　synthesized　by　a　two-step　method.　First,　the　magnetic　nanoparticles　(MNPs)　coated　with　dextran　(M　w　≈　20000)　were　prepared　by　co-precipitation　of　Fe　2+　and　Fe　3+　ions.　Then,　dextran　on　the　surface　of　MNPs　reacted　with　monochloroacetic　acid　(MCA)　in　alkaline　condition.　The　influences　of　temperature　and　reactant　concentration　on　the　amount　of　-COOH　on　the　surface　of　nanoparticles　were　systematically　studied.　The　obtained　MNPs　coated　with　CM-dextran　were　stable　over　the　entire　range　of　pH　and　NaCl　concentration.　The　MRI　experiment　indicated　that　the　CM-dextran　MNPs　could　potentially　be　used　as　MRI　contrast　agents　for　magnetic　resonance　molecular　imaging.　©　2011　Elsevier　B.V.　All　rights　reserved.

Keyword：

Carboxymethyl dextran; Magnetic nanoparticle; Monochloroacetic acid; MRI

Community：

[ 1 ] [Liu, G.]College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Organic Synthesis of Jiangsu Province, Soochow University, Suzhou 215123, China
[ 2 ] [Hong, R.Y.]College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Organic Synthesis of Jiangsu Province, Soochow University, Suzhou 215123, China
[ 3 ] [Hong, R.Y.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China
[ 4 ] [Hong, R.Y.]State Key Laboratory of Multi-phase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China
[ 5 ] [Hong, R.Y.]College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China
[ 6 ] [Hong, R.Y.]Soochow University, Chemical Engineering Department No. 199, Ren-Ai Str., Suzhou, Jiangsu 215123, China
[ 7 ] [Guo, L.]MRI Division, First Affiliated Hospital, Soochow University, Suzhou 215007, China
[ 8 ] [Li, Y.G.]MRI Division, First Affiliated Hospital, Soochow University, Suzhou 215007, China
[ 9 ] [Li, H.Z.]State Key Laboratory of Multi-phase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China

Reprint 's Address：

Email：

rhong@suda.edu.cn

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Source ：

Applied Surface Science

ISSN： 0169-4332

Year： 2011

Issue： 15

Volume： 257

Page： 6711-6717

2 . 1 0 3

JCR@2011

6 . 3 0 0

JCR@2023

JCR Journal Grade：1

CAS Journal Grade：2

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