Objective:　By　bioinformatics　method,　the　effect　in　hematopoietic　system　of　bioactive　peptide　HP-6,　which　was　obtained　from　donkey　serum　albumin　and　is　one　of　the　major　protein　components　from　donkey-hide　gelatin,　was　investigated.　Method:　Human　bone　marrow　nucleated　cells　(hBMNCs)　and　murine　bone　marrow　stromal　cells　(mBMSCs)　were　separated　and　cultured　with　different　concentration　of　peptide　HP-6　(0.000　15,0.001　5,0.015,0.　15,1.5　μmol·L　-1).　The　effect　on　promoting　proliferation　of　cells　related　to　hematopoiesis　in　bone　morrow　was　detected　and　the　ultrastructure　of　cells　after　treated　by　HP-6　was　observed　through　transmission　electron　microscope.　Hemorrhage　anemia　mouse　model　and　anemia　mouse　model　induced　by　cyclophosphamide　were　established,　and　randomly　divided　into　peptide　HP-6　groups　which　were　administered　respectively　with　different　doses　(1,0.　1,0.01　mg·　kg　-1)　by　gavage,　and　control　group　which　was　administered　with　PBS　by　gavage.　Peripheral　blood　components　of　all　mice　and　bone　morrow　cells　(BMC)　number　of　mice　induced　by　cyclophosphamide　were　evaluated.　Result:　Peptide　HP-6　could　concentration-related　promote　the　proliferation　of　hBMNCs　and　mBMSCs,　hBMNCs　got　the　highest　reproduction　rate　of　152.11%　and　mBMSCs　also　got　63.52%　with　the　concentration　of　0.15　μmol·L　-1,　then　the　reproduction　rate　decreased　while　the　concentration　kept　increasing.　The　transmission　electron　microscope　showed　that　ultrastructure　of　cells　was　normal　after　treated　by　HP-6.　1　mg·kg　-1　peptide　HP-6　significandy　increased　peripheral　platelet　and　protected　mouse　morrow　injured　by　cyclophoshamide.　0.1　mg·kg　-1　peptide　HP-6　significantly　increased　peripheral　platelet　with　relative　growth　rate　of　77.65　%,　increased　peripheral　white　blood　cells　count　and　peripheral　red　blood　cells　count,　also　could　protect　mouse　peripheral　blood　after　treated　by　chemotherapeutics.　Conclusion:　Peptide　HP-6　could　promote　the　proliferation　of　cells　related　to　hematopoietic　system,　enhance　mouse　hemopoiesis　function　and　the　resistance　to　chemotherapeutic　injury.