In　order　to　research　the　effects　of　soil-structure　interaction　(SSI)　on　structural　vulnerability　analysis　for　concrete-filled　steel　tubular　(CFST)　frame,　two　finite　element　models,　where　the　spring-damping　unit　is　used　to　simulate　the　soil,　are　built　to　simulate　a　four-story　CFST　frame　with　rigid　connections　and　with　considering　SSI.　The　modal　analysis,　seismic　response　and　earthquake　vulnerability　analysis　are　conducted.　The　relationship　curves　of　structural　damage　deformation　and　damage　excess　probability　are　obtained　for　different　structural　systems,　sites　and　earthquake　waves.