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author：

Chen, L. (Chen, L..) [1] | Li, D.-H. (Li, D.-H..) [2] | Cai, S.-X. (Cai, S.-X..) [3] | Wang, F.-P. (Wang, F.-P..) [4] | Xiao, X. (Xiao, X..) [5] | Gu, Q.-Q. (Gu, Q.-Q..) [6]

Indexed by：

Scopus PKU CSCD

Abstract：

A　new　sesquiterpene　hydroquinone　(1)　was　isolated　from　a　deep　sea　sediment　derived　fungus,　Phialocephala　sp..　Its　structure　and　stereochemistry　were　established　on　the　basis　of　spectroscopic　data　and　optical　rotation.　This　compound　was　tested　for　cytotoxicity　against　P388　(murine　leukemia　cell)　and　K562　(human　leukemia　cell)　cell　lines,　and　displayed　strong　cytotoxic　effects　with　IC50　value　of　0.16　and　0.05　μmol·L-1,　separately.

Keyword：

Cytotoxic activity; Fungal secondary metabolite; Sesquiterpene hydroquinone

Community：

  • [ 1 ] [Chen, L.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, China
  • [ 2 ] [Chen, L.]Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
  • [ 3 ] [Li, D.-H.]Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
  • [ 4 ] [Cai, S.-X.]Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
  • [ 5 ] [Wang, F.-P.]School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
  • [ 6 ] [Xiao, X.]School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
  • [ 7 ] [Gu, Q.-Q.]Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China

Reprint 's Address：

  • [Gu, Q.-Q.]Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China

Email：


guqianq@ouc.edu.cn
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Source ：

Yaoxue Xuebao

ISSN： 0513-4870

CN： 11-2163/R

Year： 2010

Issue： 10

Volume： 45

Page： 1275-1278

Cited Count：

WoS CC Cited Count： 0

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

Affiliated Colleges：

生物科学与工程学院 本学院/部未明确归属的数据

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