Amplified aptamer-based assay through catalytic recycling of the analyte - Details

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Abstract：

Turn　up　the　volume:　In　a　simple　and　highly　sensitive　aptamer-based　assay　that　relies　on　the　ability　of　nanomaterials　to　protect　DNA　from　nuclease　cleavage,　the　aptamer　is　released　from　the　nanomaterial　when　challenged　with　a　target.　The　nuclease　then　cleaves　the　free　aptamer　and　releases　the　target,　which　can　initiate　a　new　cycle.　Recycling　of　the　target　in　this　way　leads　to　significant　signal　amplification　(see　diagram).　©　2010　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim.

Keyword：

Aptamers; Biological assays; Graphene; Nanomaterials; Nucleases

Community：

[ 1 ] [Lu, C.-H.]Key Laboratory of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China
[ 2 ] [Li, J.]Key Laboratory of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China
[ 3 ] [Lin, M.-H.]Key Laboratory of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China
[ 4 ] [Wang, Y.-W.]Key Laboratory of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China
[ 5 ] [Yang, H.-H.]Key Laboratory of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China
[ 6 ] [Chen, X.]Key Laboratory of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China
[ 7 ] [Chen, G.-N.]Key Laboratory of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China

Reprint 's Address：

[Lu, C.-H.]Key Laboratory of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China

Email：

hhyang@fio.org.cn

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Source ：

Angewandte Chemie - International Edition

ISSN： 1433-7851

Year： 2010

Issue： 45

Volume： 49

Page： 8454-8457

1 2 . 7 3

JCR@2010

1 6 . 1 0 0

JCR@2023

JCR Journal Grade：1

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WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

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