In　this　work　we　describes　the　design　and　engineering　of　a　floating-point　(FP)　data-acquisition　system　for　16-channel　electrochemical　(EC)　measurement.　The　system　has　both　automatic　gain　and　peak　detection　feature.　The　gain　is　set　automatically　dependent　on　the　input　amplitude　so　that　at　least　13-bit　conversion　resolution　is　maintained　for　the　EC　signal　in　the　wide　range　from　48nA　to　16mA.　Peak　detectors　(PD)　are　used　to　acquire　the　peak　signal　accurately　and　automatically　to　avoid　missing　important　information　in　the　multi-channel　EC　detection.　The　system　consists　of　16　uniform　automatic　gain　control　(AGC)　subsystems　that　operate　in　parallel.　Compared　with　most　of　the　other　AGC　systems,　the　mixed　analog/digital　implementation　presented　here　operates　without　ADC　sampling　and　software　processing,　so　that　the　gain-setting　time　is　minimized　to　20ns.　For　the　simple　but　efficient　control　mechanism,　all　digital　circuits　of　the　system　can　be　integrated　into　a　small-scale　FPGA　chip.　Compared　with　commercial　EC　instrument,　these　characters　make　this　FP　data-acquisition　system　ideal　for　in　situ　or　field　multi-channel　EC　measurements.　©2010　IEEE.