Speradines B-E, four novel tetracyclic oxindole alkaloids from the marine-derived fungus aspergillus oryzae - Details

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Abstract：

Four　novel　tetracyclic　oxindole　alkaloids,　namely,　speradines　B　(1),　C　(2),　D　(3),　and　E　(4)　were　isolated　from　the　marine-derived　fungus　Aspergillus　oryzae.　The　structures　of　these　compounds　without　the　absolute　configurations　were　elucidated　through　1D　and　2D　nuclear　magnetic　resonance　and　high-resolution　mass　spectrometric　analyses.　Among　these　compounds,　1　and　4　showed　weak　cytotoxic　effects　on　the　HeLa　cell　line.　©　2014　The　Japan　Institute　of　Heterocyclic　Chemistry.

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[ 1 ] [Hu, X.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 2 ] [Hu, X.]School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China
[ 3 ] [Xia, Q.-W.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 4 ] [Zhao, Y.-Y.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 5 ] [Zheng, Q.-H.]Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Provincial Cancer Hospital, Fuzhou, 350014, China
[ 6 ] [Liu, Q.-Y.]Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Provincial Cancer Hospital, Fuzhou, 350014, China
[ 7 ] [Chen, L.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 8 ] [Zhang, Q.-Q.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 9 ] [Zhang, Q.-Q.]Institute of Biomedical Engineering, Chinese Academy of Medical Science, Peking Union Medical College, Tianjin, 300192, China

Reprint 's Address：

[Chen, L.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China

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ibptcl@fzu.edu.cn

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Heterocycles

ISSN： 0385-5414

Year： 2014

Issue： 7

Volume： 89

Page： 1662-1669

1 . 0 7 9

JCR@2014

0 . 8 0 0

JCR@2023

ESI HC Threshold：268

JCR Journal Grade：3

CAS Journal Grade：4

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SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 2

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