Regular　RC　(reinforced　concrete)　3D　spatial　frames　with　different　transverse　beam　stiffness　subjected　to　lateral　loading　were　simulated　in　ABAQUS,　which　were　designed　strictly　according　to　the　Chinese　code　of　3rd　aseismic　grade.　In　order　to　reflect　the　real　structure　mechanical　performance　and　the　implementation　effect　of　strong　column-weak　beam,　a　solid　element　was　used　to　simulate　the　concrete　of　frames.　On　the　basis　of　simulation　and　theoretical　analyzation,　a　moment　augment　factor　of　column　which　took　the　influence　of　transverse　beam　stiffness　in　consideration　was　suggested　and　verified.　The　results　shows　that　when　the　value　of　moment　augment　factor　of　column　takes　for　1.5,　the　implementation　effect　of　strong　column-weak　beam　principle　can　be　well　improved　and　only　takes　a　few　increase　in　the　construction　cost.　Therefore,　the　recommended　value　of　moment　augment　factor　of　column　can　be　adopted　in　actual　structural　design.