pH-sensitive　hydrogels　(non-imprinted　hydrogels,　NIP)　were　synthesized　by　solution　polymerization　with　hydroxyethyl　methacrylate,　methacrylic　acid　and　acrylamide　as　functional　monomers,　and　ethylene　glycol　dimethylacrylate　as　cross-linking　agent.　The　swelling　property　and　pH-sensitivity　of　NIP　were　investigated.　Glucose　imprinted　hydrogels　(imprinted　hydrogels,　MIP)　were　prepared　by　introducing　glucose　as　template　into　the　above　reaction　system.　The　results　showed　that　the　monomers　and　cross-linking　agent　had　a　certain　degree　of　effects　on　the　swelling　ratio　of　NIP　and　the　swelling　ratio　was　close　to　the　maximum　in　the　pH　range　of　6-7.　NIP　showed　obvious　pH-responsive　reversibility.　MIP　possesses　the　identification　of　glucose,　and　its　imprinting　factor　could　reach　1.73.　The　responses　of　MIP　and　NIP　to　pH　are　similar,　but　the　swelling　ratio　of　MIP　is　smaller.